Fluoroacetate as a possible marker for glial metabolism in vivo / Donald D. Clarke, Ph.D. and Soll Berl, M. D. Dept. of Chemistry, Fordham Univ. and Dept. of Neurology, Mt. Sinai School of Medicine Bronx, N.Y. 10458 and New York, N.Y. 10029

Authors

Donald Dudley Clarke PhD, Fordham UniversityFollow
Soll Berl, Mount Sinai School of Medicine
Donald Dudley Clarke PhD, Fordham UniversityFollow

Document Type

Article

Disciplines

Biochemistry

Abstract

Glucose is the major source of energy in all brain cells and its metabolism is closely coupled to functional activity. Advantage has been taken of this by Sokoloff (1977) and Sokoloff et al. (1977) to study energy metabolism in different brain areas and their response to a variety of drugs and stimuli. For this purpose these workers have developed the procedure for mrasuring autoradiographically the accumulation of [14C]-deoxyglucose into its phosphate derivative, a compound which does not differentiate glial from neuronal metabolism. They could be enhanced if one could differentiate glial from neuronal metabolic response to the various experimental conditions. Conceivably, one could then study the effect of glial metabolism on neuronal metabolism and vice versa

Article Number

1026

Publication Date

1983

Recommended Citation

Clarke, Donald Dudley PhD; Berl, Soll; and Clarke, Donald Dudley PhD, "Fluoroacetate as a possible marker for glial metabolism in vivo / Donald D. Clarke, Ph.D. and Soll Berl, M. D. Dept. of Chemistry, Fordham Univ. and Dept. of Neurology, Mt. Sinai School of Medicine Bronx, N.Y. 10458 and New York, N.Y. 10029" (1983). Chemistry Faculty Publications. 27.
https://research.library.fordham.edu/chem_facultypubs/27

Comments

Glutamine, glutamate, and GABA in the central nervous system pages 233-240