Glutamine, glutamate, and GABA in the central nervous system pages 233-240




Glucose is the major source of energy in all brain cells and its metabolism is closely coupled to functional activity. Advantage has been taken of this by Sokoloff (1977) and Sokoloff et al. (1977) to study energy metabolism in different brain areas and their response to a variety of drugs and stimuli. For this purpose these workers have developed the procedure for mrasuring autoradiographically the accumulation of [14C]-deoxyglucose into its phosphate derivative, a compound which does not differentiate glial from neuronal metabolism. They could be enhanced if one could differentiate glial from neuronal metabolic response to the various experimental conditions. Conceivably, one could then study the effect of glial metabolism on neuronal metabolism and vice versa

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