Effects of LI+ on the metabolism in brain of glutamate, glutamine, aspartate and gaba from [I-14]acetate in vitro / S. Berl and D. D. Clarke Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032 and Chemistry Department, Fordham University, Bronx, N.Y. 10458 (U.S.A.)

Authors

Soll Berl, Columbia University. College of Physicians and Surgeons. Department of Neurology
Donald Dudley Clarke PhD, Fordham UniversityFollow

Document Type

Article

Disciplines

Biochemistry

Abstract

Guinea pig brain slices were incubated in media in which Li+ replaced part of the Na+. Leakage of glutamic acid, glutamine, aspartic acid and GABA into the media were increased markedly; glutamic acid was most affected. The uptake of [1-14C]acetate was decreased in the presence of Li+. Of the amino acids related to the citric acid cycle the labeling of glutamine was most affected. The presence of 100% O2 counteracts in part the Li+ effects. The results were interpretable on the basis of the compartmentation of citric acid cycle metabolism in brain. It is suggested that the pool of 'transmitter' glutamate is related to the small pool of glutamate which actively labels glutamine

Article Number

1030

Publication Date

1972

Recommended Citation

Berl, Soll and Clarke, Donald Dudley PhD, "Effects of LI+ on the metabolism in brain of glutamate, glutamine, aspartate and gaba from [I-14]acetate in vitro / S. Berl and D. D. Clarke Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032 and Chemistry Department, Fordham University, Bronx, N.Y. 10458 (U.S.A.)" (1972). Chemistry Faculty Publications. 31.
https://research.library.fordham.edu/chem_facultypubs/31

Comments

Brain research. 36:203-213. http://dx.doi.org/10.1016/0006-8993(72)90776-7