Document Type
Article
Disciplines
Biochemistry
Abstract
Antifungal studies were made of mixtures of minimal inhibitory concentrations (MICs) of 8-quinolinol and its bischelates with copper(II), zinc(II), and manganese(II) and with mixed ligand chelates composed of 8-quinolinol, copper(II) and a second ligand including salicylic acid, 3-hydroxy-2-naphthoic acid, 3,5-diiodosalicylic acid, and 4-bromo-3-hydroxy-2-naphthoic acid. Mixtures of the MICs of the bischelates of 8-quinolinol with copper(II) and zinc(II) and copper(II) and manganese(II), as well as 7-iodo-8-quinolinol and its bischelate with copper(II), and 8-quinolinol and 5-iodo-8-quinolinol were also studied against six fungi: Aspergillus niger, Aspergillus oryzae, Trichoderma viride, Myrothecium verrucaria, Mucor cirinelloides, and Trichophyton mentagrophytes. With the exceptions of the mixtures of 8-quinolinol and (8-quinolinolato )(3,5-diiodosalicylato )copper(II) and (8-quinolinolato)(4- bromo-3-hydroxy-2-naphthoato)copper(II) against M. cirinelloides, all of the test organisms were inhibited by 40% or less of each mixture containing 8-quinolinol. Bischelates of 8-quinolinol with copper(II) and zinc(II) and copper(II) and manganese(II) inhibited five fungi at 50% of the mixtures of the MICs. Mucor cirinelloides was not inhibited by bis(8-quinolinolato)copper(II), bis(8-quinolinolato)zinc(II), or by bis(7- iodo-8-quinolinolato)copper(II). The following conclusions were drawn: (1) there is synergism between 8-quinolinols and their metal chelates; (2) the mechanisms of fungitoxicity of 8-quinolinols and their metal chelates are different; (3) the fungitoxic actions of the chelates of 8-quinolinols with different metals appear to be additive; (4) the mechanisms of fungitoxicity of 8-quinolinol and 5-iodo-8-quinolinol are different; (5) the toxicity of 8-quinolinols is due to the concerted action of the ligands and their metal chelates, whereas when the toxicant is the preformed metal chelate, toxicity is due to the chelate alone
Article Number
1062
Publication Date
1989
Recommended Citation
Gershon, Herman; Clarke, Donald Dudley PhD; and Gershon, Muriel, "Synergistic antifungal action of 8-quinoinol and its bischelate with copper(II) and mixed ligand chelates composed of coper(II), 8-quinolinol, and aromatic hydroxy acids / Herman Gershon, Donald D., Clarke, and Muriel Gershon" (1989). Chemistry Faculty Publications. 63.
https://research.library.fordham.edu/chem_facultypubs/63
Comments
American pharmaceutical association 78 no. 11:975-978. 0022-3549/89/1100-0975$01.00/0