Further evidence that geometries of fungicides and pores in fungal wall must be compatible to show bioavailability / Herman Gershon, Muriel Gershon, and Donald D. Clark Harding Laboratory, the New York Botanical Garde, Fordham University, Bronx, New York 10458, USA

Authors

Herman Gershon, New York Botanical Garden. Harding Laboratory
Muriel Gershon, New York Botanical Garden. Harding Laboratory
Donald Dudley Clarke PhD, Fordham UniversityFollow

Document Type

Article

Keywords

bis(3-bromo-6-chloro-8-quinolinolato) copper(II), bis(6-bromo-3-chloro-8-quinolinolato) copper(II), fungitoxicants, penetration of pores, pore geometry, toxicant geometry

Disciplines

Biochemistry

Abstract

Copper(II) biscomplexes of 3-bromo-6-chloro-8- quinolinol and 6-bromo-3-chloro-8-quinolinol were prepared, the long axes ofwhich were 16.8 A and 17.6 A respectively. The long axes of the pores in the walls of the test fungi were determined: A niger (15.0 A), A. oryzae (16.8 A), M verrucaria (17.4 A), T viride (15.0 A). M circinelloides (not determined), and T mentagrophytes (11 .4 A). When the long axis of the copper(II) complex was was shorter or equal to that of the pore, there was fungitoxicity. When the long axis of the complex was longer than that of the pore in the fungal wall there was no toxicity. This was due to penetration or exclusion from the cell

Article Number

1008

Publication Date

2006

Recommended Citation

Gershon, Herman; Gershon, Muriel; and Clarke, Donald Dudley PhD, "Further evidence that geometries of fungicides and pores in fungal wall must be compatible to show bioavailability / Herman Gershon, Muriel Gershon, and Donald D. Clark Harding Laboratory, the New York Botanical Garde, Fordham University, Bronx, New York 10458, USA" (2006). Chemistry Faculty Publications. 9.
https://research.library.fordham.edu/chem_facultypubs/9

Comments

Current trends in medicinal chemistry. 4:57-59