Most biologically active compounds, including pharmaceuticals, have chiral molecular structures. With increased recognition that enantiomers of chiral drugs are metabolized differently, there has been enormous interest in the development of enantioselective methodologies for the synthesis of chiral compounds. NMR spectroscopy has emerged as a powerful method for discrimination of enantiomers of chiral compounds. 1 One strategy by which the NMR method is exploited is based on converting the enantiomers of a chiral compound to diastereomers using a chiral derivatizing agent. These diastereomers often display anisochronous NMR signals, which can be identified and integrated affording quantitative measurements of the optical purity of a sample.
Bondi, Steven FCRH '11; Lobasso, Thomas FCRH '09; Iwanoski, Christa FCRH '09; Saba, Shahrokh; and Clarke, Donald
"NMR Determination of Enantiomeric Composition of Chiral Alcohols Using Camphorsulfonate Esters,"
Fordham Undergraduate Research Journal:
1, Article 10.
Available at: http://fordham.bepress.com/furj/vol1/iss1/10