Title

GM1 ganglioside reduces behavioral dysfunction following cortical focal ischemia

Disciplines

Psychology | Social and Behavioral Sciences

Abstract

The functional consequences of corticalfocalischemia and the effect of monosialoganglioside (GM1) treatment on learning/performance of a spatial reversal task were investigated. Corticalfocalischemia was induced by a permanent occlusion of the left common carotid artery and the ipsilateral middle cerebral artery, with a 1-h clamping of the contralateral carotid artery. Twenty-six rats were randomly assigned to three groups: sham controls, a saline-treated ischemic group, and a GM1ganglioside-treated ischemic group (10 mg/kg/day: IM). Fifteen days after surgery rats were trained on a spatial reversal task in a two-lever operant chamber where food reward was contingent on lever pressing. Training continued from day 15 to day 21 after surgery. Corticalfocalischemia resulted in learning/performance deficits that were reduced byGM1ganglioside treatment. The cognitive deficits were characterized by a significantly higher number of nonperseverative erros and number of responses to criterion. There was a significant difference between left and right lever performance in the saline-treated ischemic group, which was absent in shams and GM1-treated ischemic rats. On all mearures GM1-treated rats were not different from sham controls.