Document Type

Article

Keywords

antifungal activity, halogenated 8-quinolinol-5- and 7-sulfonic acids, halogenated 8-quinolinol-2- methyl-5- and 7-sulfonic acids, intramolecular synergism

Disciplines

Biochemistry

Abstract

8-Quinolinol-5-sulfonic acid was nearly devoid of antimicrobial activity, due to what was believed to be an unfavorable partition coefficient. Since twenty six 8-quinolinol-5- and 7 -sulfonic acids were available from our previous work, they were tested against six fungi. The 7 -chloro and 7 -bromo-5-sulfonic acids and the 5-chloro and 5-bromo-7 -sulfonic acids showed fungal inhibition within one order of magnitude of that of 8-quinolinol. It is suggested that a nonchelating mechanism is in part responsible for this fungitoxicity. Five additional 5-sulfonic acids with chlorine in positions 3-, 6-, 3,6-, 3,7-, and 6,7- that were suitable for studies in synergism became available more recently. The enhanced activities of the dichlorosulfonic acids over the correspondingly substituted monochlorosulfonic acids is attributed to intramolecular synergism

Article Number

1011

Publication Date

2001

Comments

Mycopathologia 155:213-217

Included in

Biochemistry Commons

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