Acetylation of synaptosomal protein: inhibition of veratridine / Soll Berl, Ramiro Nunez, Arlene D. Colon, and Donald D. Clarke Mount Sinai School of MEdicine, and Chemistry Department, Fordham University, New York, New York, U.S.A.

Authors

Soll Berl, Mount Sinai School of Medicine
Ramiro Nunez, Mount Sinai School of Medicine
Arlene D. Colon, Mount Sinai School of Medicine. Department of Neurology
Donald Dudley Clarke PhD, Fordham UniversityFollow

Document Type

Article

Keywords

Acetylation, Synaptosomes, Proteins, Veratridine, Tetrodotoxin

Disciplines

Biochemistry

Abstract

Incubation of synaptosomes with [3H]acetate results in rapid labeling of protein. Labeling is decreased in the presence of veratridine, and the effect of veratridine is blocked by tetrodotoxin. Most of the radioactivity can be removed by base or acid hydrolysis, and is probably incorporated as acetate; it is this fraction that is affected by the veratridine. The data suggest that veratridine stimulates deacetylation of synaptosomal protein. This raises the question whether acetylation-deacetylation is involved in membrane function

Article Number

1024

Publication Date

1983

Recommended Citation

Berl, Soll; Nunez, Ramiro; Colon, Arlene D.; and Clarke, Donald Dudley PhD, "Acetylation of synaptosomal protein: inhibition of veratridine / Soll Berl, Ramiro Nunez, Arlene D. Colon, and Donald D. Clarke Mount Sinai School of MEdicine, and Chemistry Department, Fordham University, New York, New York, U.S.A." (1983). Chemistry Faculty Publications. 25.
https://research.library.fordham.edu/chem_facultypubs/25

Comments

Journal of neurochemistry. pages 176-183. 0022-3042/83/0101-0176/$03.00/0