Antagonists of N-methyl-d-aspartate receptor partially prevent the development of cocaine sensitization
Document Type
Article
Disciplines
Psychology | Social and Behavioral Sciences
Abstract
Behavioral sensitization to cocaine was tested for in rats pretreated with MK-801, a noncompetitive ^À/-methyl-D-aspartate (NMDA) receptor antagonist, or D-3-(2-carborypiperaan-4-yl)-l-propenyl-l-phosphonic acid (D-CPPene), a competitive NMDA antagonist. A 5-day regimen of once-daily ssç¡ine (15 mglkg) injections yielded sensitization to cocaine (15 mglkg)-induced behavioral activation. Cocaine sensitiz¿tion lilas partially prevented by MK-801 (0.25 m/kg) or D-CPPene (2A mdks) pretreatment. These rezults differ from previous reports that NMDA receptor antagonists completely prevented tåe development of stimulant sensitization. While raising questions about methodological differences among laboratories studying this iszue, our findings suggest that sensitization may involve mechanisms dependent on NMDA-receptor function as well as NMDA receptor-independent mechanisms.
Article Number
1189
Publication Date
1995
Recommended Citation
Haracz, J., S. Belanger, J. S. MacDonall, and R. Sircar (1995). Antagonists of N-methyl-d-aspartate receptor partially prevent the development of cocaine sensitization. Life Science, 57, 2347-2357.
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